姓名：孙文献
性别：男
毕业院校：Ohio University
最高学位：博士
职称：教授
办公地址：长春市新城大街2888号吉林农业大学
办公电话：0431-84532780
电子邮箱：wxs@cau.edu.cn
个人简介：
学习经历：
1988.09–1992.07：南京农业大学农学系农学专业 学士
1992.09–1995.07：南京农业大学农学系作物遗传育种专业 硕士
1999.01–2003.12：Ohio University(俄亥俄大学)生物学系 细胞与分子生物学 博士
科研工作经历：
1995年8月至1996年8月：南京农业大学农学系细胞遗传研究所 助教
1996年8月至1998年12月：南京农业大学农学系细胞遗传研究所 讲师
2004年1月至2008年10月：威斯康星大学 植物病理系 博士后
2008年11月：中国农业大学教授
2018年：吉林农业大学教授
研究方向：
水稻与病原菌的分子互作（以稻曲病与细菌性条斑病菌为主）
植物PAMP诱导抗性的分子机理
水稻病原菌的毒性与致病力的分子基础
主要代表性论文：
2021年
1. Ziyan Xu† , Yongjie Kuang† , Bin Ren† , Daqi Yan, Fang Yan, Carl Spetz, Wenxian Sun, Guirong Wang, Xueping Zhou*, Huanbin Zhou* . SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition. Genome Biology 2021, 22:6
2020年
2. Yanqing Han†, Deqiang Li†, Jun Yang , Fu Huang , Hongyan Sheng and Wenxian Sun*.Mapping quantitative trait loci for disease resistance to false smut of rice. Phytopathology Research (2020) 2:20 https://doi.org/10.1186/s42483-020-00059-6 , IF= 3.234
3. Wenxian Sun†, Jing Fan†, Anfei Fang, Yuejiao Li, Muhammad Tariqjaveed, Dayong Li, Dongwei Hu, Wen-Ming Wang. Ustilaginoidea virens: Insights into an Emerging Rice Pathogen. Annu. Rev. Phytopathol. 2020. 58:3.1–3.23 doi.org/10.1146/annurev-phyto-010820- 012908，IF= 12.623(2019)
2019年
4. Nan Zhang, Jiyun Yang, Anfei Fang, Jiyang Wang, Dayong Li , Yuejiao Li ,Shanzhi Wang, Fuhao Cui , Junjie Yu, Yongfeng Liu, Youliang Peng* ,Wenxian Sun*.The essential effector SCRE1 in Ustilaginoidea virens suppresses rice immunity via a small peptide region.Molecular Plant Pathology, DOI: 10.1111/mpp.12894, IF= 4.361
5. Kai Zhang †, Yehui Xiong †, Wenxian Sun , Guoliang Wang Wende Liu*. Global Proteomic Analysis Reveals Widespread Lysine Succinylation in Rice Seedlings .
Int. J. Mol. Sci. 2019, 20(23), 5911; doi.org/10.3390/ijms 20235911 ,IF= 4.183
6. Shuai Li*, Xunwen Peng, Yingling Wang, Kangyu Hua, Fan Xing, Yuanyuan Zheng, Wei Liu, Wenxian Sun* and Songhong Wei*. The Effector AGLIP1 in Rhizoctonia solani AG1 IA Triggers Cell Death in Plants and Promotes Disease Development Through Inhibiting PAMP-Triggered Immunity in Arabidopsis thaliana. Front. Microbiol., doi: 10.3389/fmicb.2019.02228 26 September 2019 ，IF= 4.259
7. Muxing Liu, Suobing Zhang, Jiexiong Hu, Wenxian Sun, Jonas Padilla, Yanglan He,
Ying Li, Ziyi Yin, Xinyu Liu, Wenhao Wang, Danyu Shen, Dayong Li, Haifeng Zhang, Xiaobo Zheng, Zhongli Cui,Guo-Liang Wang, Ping Wang, Bo Zhou,Zhengguang Zhang*.
Phosphorylation-guarded light-harvesting complex II contributes to broad-spectrum blast resistance in rice,Proc. Nat. Acad. Sci. U.S.A. doi/10.1073/pnas.1905123116
8. Anfei Fang, Han Gao, Nan Zhang, Xinhang Zheng, Shanshan Qiu, Yuejiao Li,
Shuang Zhou, Fuhao Cui and Wenxian Sun*. A Novel Effector Gene SCRE2 Contributes to Full Virulence of Ustilaginoidea virens to Rice., Frontiers in Microbiology(4.019), doi: 10.3389/fmicb.2019.00845
9. Yuejiao Li#, Ming Wang, Zhaohui Liu, Kang Zhang, Fuhao Cui, Wenxian Sun* (2019)
Towards understanding the biosynthetic pathway for ustilaginoidin mycotoxins in Ustilaginoidea virens. Environ. Microbiol. ,21(8), 2629–2643 DOI: 10.1111/1462-2920.14572
2018年
10. Jiyang Wang, Shanzhi Wang, Ke Hu, Jun Yang, Xiaoyun Xin, Wenqing Zhou, Jiangbo Fan, Fuhao Cui, Baohui Mou, Shiyong Zhang, Guo-Liang Wang, Wenxian Sun *(2018) The kinase OsCPK4 regulates a buffering mechanism that fine-tunes innate immunity. Plant Physiol. ,176:1835–1849.
11. Qianqian Shi#, Zhenchuan Mao, Xi Zhang, Xiaoping Zhang, Yunsheng Wang, Jian Ling, Runmao Lin, Denghui Li, Xincong Kang, Wenxian Sun, Bingyan Xie*(2018) A Meloidogyne incognita effector MiISE5 suppresses programmed cell death to promote parasitism in host plant. Sci. Rep. , 8: 7256
12. Feng He#, Fan Zhang, Wenxian Sun, Yuese Ning*, Guo-Liang Wang*(2018) A Versatile Vector Toolkit for Functional Analysis of Rice Genes. Rice, 11:27
13. Feng He#, Fan Zhang, Wenxian Sun, Yuese Ning*, Guo-Liang Wang*(2018) Correction to: A Versatile Vector Toolkit for Functional Analysis of Rice Genes. Rice, 11:49
14. Fuhao Cui#, Wenxian Sun, Xiangpei Kong (2018) RLCKs Bridge Plant Immune Receptors and MAPK Cascades. Trends Plant Sci., 23:1039-1041
2017年
15. Kang Zhang, Tengjiao Li, Yuejiao Li, Zhi-Gang Li, Tom Hsiang, Ziding Zhang and Wenxian Sun* (2017) Pathogenicity genes in Ustilaginoidea virens revealed by a predicted protein-protein interaction network. J Proteome Res. 16(3):1193-1206. doi: 10.1021/acs.jproteome.6b00720.
16. Guo T, Wang XW, Shan K, Sun Wenxian, Guo LY. The Loricrin-Like Protein (LLP) of Phytophthora infestans Is Required for Oospore Formation and Plant Infection. Front Plant Sci. 2017 Feb 9;8:142. doi: 10.3389/fpls.2017.00142.
17. Lijuan Liu, Yanping Wang, Fuhao Cui, Anfei Fang, Shanzhi Wang, Jiyang Wang, Chao Wei, Shuai Li and Wenxian Sun*. The type III effector AvrXccB in Xanthomonas campestris pv. campestris targets putative methyltransferases and suppresses innate immunity in Arabidopsis. (2017) Mol. Plant Pathol. 18（6）：768-782. 10.1111/mpp.12435.
2016年
18. Anfei Fang, Yanqing Han, Nan Zhang, Min Zhang, Lijuan Liu, Shuai Li, Fen Lu, and Wenxian Sun*. Identification and characterization of plant cell death–inducing secreted proteins from Ustilaginoidea virens. (2016) Mol Plant Microbe Interact 29(5): 405-416.
19. Chao Wei, Wendi Jiang, Mengran Zhao, Junjie Ling, Xin Zeng, Jun Deng, Dongli Jin, John Maxwell Dow and Wenxian Sun*. A systematic analysis of the role of GGDEF-EAL domain proteins in virulence and motility in Xanthomonas oryzae pv. oryzicola. Sci Rep. (2016) 6: 23769.
20. Jun-Jie Yu, Mi-Na Yu, Ya-Feng Nie, Wen-Xian Sun, Xiao-Le Yin, Jie Zhao, Ya-Hui Wang, Hui Ding, Zhong-Qiang Qi, Yan Du, Li Huang, Yong-Feng Liu. Comparative transcriptome analysis of fruiting body and sporulating mycelia of Villosiclava virens reveals genes with putative functions in sexual reproduction. (2016) Current Genetics 62(3): 575~584
2015年
21. Yanqing Han, Kang Zhang, Jun Yang, Nan Zhang, Anfei Fang, Yong Zhang, Yongfeng Liu, Zhiyi Chen, Tom Hsiang Wenxian Sun*. Differential expression profiling of the early response to Ustilaginoidea virens between false smut resistant and susceptible rice varieties. BMC Genomics (2015) 16:955.
22. Jun-jie Yu, Wen-xian Sun, Mi-na Yu, Xiao-le Yin, Xiang-kun Meng, Jie Zhao, Lei Huang, Li Huang and Yong-feng Liu (2015) Characterization of mating-type loci in rice false smut fungus Villosiclava virens. FEMS Microbiology Letters, 362, 2015 fnv014
23. Shuai Li, Yanping Wang, Shanzhi Wang, Anfei Fang, Jiyang Wang, Lijuan Liu, Kang Zhang, Yuling Mao and Wenxian Sun* (2015) The Type III Effector AvrBs2 in Xanthomonas oryzae pv. oryzicola suppresses rice immunity and promotes disease development. Mol Plant Microbe Interact 28(8): 869-80
24. Shanzhi Wang, Zhe Sun, Huiqin Wang, Lijuan Liu, Fen Lu, Jun Yang, Min Zhang, Shiyong Zhang, Zejian Guo, Andrew F. Bent, Wenxian Sun* (2015) Rice FLS2-mediated perception of bacterial flagellins is evaded by Xanthomonas oryzae pvs. oryzae and oryzicola. Molecular Plant, 8:1024-1037.
2014年以前
25. Fangjun Li, Cheng Cheng, Fuhao Cui, Marcos V.V. de Oliveira, Xiao Yu, Xiangzong Meng, Aline C. Intorne, Kevin Babilonia, Maoying Li, Bo Li, Sixue Chen, Xianfeng Ma, Shunyuan Xiao, Yi Zheng, Zhangjun Fei, Richard P. Metz, Charles D. Johnson, Hisashi Koiwa1, Wenxian Sun, Zhaohu Li, Gonçalo A. de Souza Filho, Libo Shan, Ping He (2014) Modulation of RNA Polymerase II Phosphorylation Downstream of Pathogen Perception Orchestrates Plant Immunity. Cell Host & Microbe 16(6): 748-758
26. Fen Lu, Huiqin Wang, Shanzhi Wang, Wendi Jiang, Changlin Shan, Bin Li, Jun Yang, Shiyong Zhang, Wenxian Sun* (2015) Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor. Journal of Integrative Plant Biology, 57(7): 641-652
27. Jing Fan, Xiao-Yi Guo, Liang Li, Fu Huang, Wenxian Sun, Yan Li, Yan-Yan Huang, Yong-Ju Xu, Jun Shi, Yang Lei, Ai-Ping Zheng and Wen-Ming Wang (2015) Infection of Ustilaginoidea virens intercepts rice seed formation but activates grain-filling-related genes. Journal of Integrative Plant Biology, 57(6):577-590.
28. Yong Zhang, Kang Zhang, Anfei Fang, Yanqing Han, Jun Yang, Minfeng Xue, Jiandong Bao, Dongwei Hu, Bo Zhou, Xianyun Sun, Shaojie Li, Ming Wen, Nan Yao, Li-Jun Ma, Yongfeng Liu, Min Zhang, Fu Huang, Chaoxi Luo, Ligang Zhou, Jianqiang Li, Zhiyi Chen, Jiankun Miao, Shu Wang, Jinsheng Lai, Jin-Rong Xu, Tom Hsiang, * Youliang Peng, * Wenxian Sun (2014) Specific adaptation of Ustilaginoidea virens in occupying host florets revealed by comparative and functional genomics, Nature Communications 5:3849, DOI: 10.1038/ncomms4849；
29. Xianyun Sun, Shu Kang, Yongjie Zhang, Xinqiu Tan, Yufei Yu, Haiyong He, Xinyu Zhang, Yongfeng Liu, Shu Wang, Wenxian Sun, Lei Cai, Shaojie Li (2013) Genetic Diversity and Population Structure of Rice Pathogen Ustilaginoidea virens in China. PLoS ONE 8(9): e76879
30. Tijiang Shan, Weibo Sun, Xiaohan Wang, Xiaoxiang Fu, Wenxian Sun and Ligang Zhou (2013) Purification of Ustiloxins A and B from Rice False Smut Balls by Macroporous Resins. Molecules 18:8181-8199.
31. Fuhao Cui, Shujing Wu, Wenxian Sun, Gitta Coaker, Barbara Kunkel, Ping He, and Libo Shan. (2013) The Pseudomonas syringae Type III Effector AvrRpt2 promotes pathogen virulence via stimulating Arabidopsis auxin/indole acetic acid protein turnover. Plant Physiology 162: 1018-1029
32. Yuanbao Zhang, Chao Wei, Wendi Jiang, Lei Wang, Churui Li, Yunyue Wang, Maxwell Dow, Sun, Wenxian* (2013) The HD-GYP domain protein RpfG of Xanthomonas oryzae pv. oryzicola regulates synthesis of extracellular polysaccharides that contribute to biofilm formation and virulence on rice. PLoS ONE 8(3): e59428.
33. Wenxian Sun, Yangrong Cao, Kristin Jansen, Bittel, P., Thomas Boller, Andrew F. Bent (2012). Probing the Arabidopsis flagellin receptor: FLS2-FLS2 association and the contributions of specific domains to signaling function. Plant Cell 24(3): 1096-1113.
34. Shan, T., Sun, W., Liu, H., Gao, S., Lu, S., Wang, M., Sun, W., Chen, Z., Wang, S., and Zhou, L. (2012). Determination and analysis of Ustiloxins A and B by LC-ESI-MS and HPLC in false smut balls of rice. Int. J. Mol. Sci. 13: 11275-11287.
35. Sun, W., Liu, L., and Bent, A.F. (2011). Type III secretion–dependent host elicitation and Type III secretion–independent growth within leaves by Xanthomonas campestris pv. campestris. Mol. Plant Pathol. 12(8):731-745.
36. Dunning, F.M., Sun, W., Jansen, K., Helft, L., and Bent, A.F. (2007). Identification and mutational analysis of Arabidopsis FLS2 leucine-rich repeat domain residues that contribute to flagellin perception. Plant Cell 19(10): 3297-3313.
37. Sun, W., Dunning, F.M., Pfund, C., Weingarten, R., and Bent, A.F. (2006). Within-species flagellin polymorphism in Xanthomonas campestris pv. campestris and its impact on elicitation of Arabidopsis FLAGELLIN SENSING2-dependent defenses. Plant Cell 18(3): 764-77.
38. Sun, W., Xu, J., Yang, J., Kieliszewski, M.J., and Showalter, A.M. (2005). The lysine-rich arabinogalactan-protein subfamily in Arabidopsis: gene expression, glycoprotein purification and biochemical characterization. Plant and Cell Physiol. 46(6): 975-984.
39. Sun, W., Kieliszewski, M.J., and Showalter, A.M. (2004). Overexpression of tomato LeAGP-1 arabinogalactan-protein promotes lateral branching and hampers reproductive development. Plant J. 40(6): 870-81.
40. Sun, W., Zhao, Z.D., Hare, M.C., Kieliszewski, M.J., and Showalter, A.M. (2004). Tomato LeAGP-1 is a plasma membrane-bound, glycosylphosphatidylinositol-anchored arabinogalactan-protein. Physiol. Plant. 120(2): 319-327 (cover article).
41. 任晓琴,孙文献,陈佩度，刘大钧. 1996, 普通小麦—大赖草6N二体异附加系的选育与鉴定.南京农业大学学报.19(3): 1-5
42. 孙文献，陈佩度，刘大钧. 1997，将大赖草种质转移给普通小麦的研究 V. 三个普通小麦-大赖草二体异附加系的选育与鉴定。南京农业大学学报20（2）：6-11
43. 孙文献， 陈佩度， 刘大钧. 1998，将大赖草种质转移给普通小麦的研究 VI. 端体异附加系的选育与鉴定。遗传学报, 25（3）：259-264
44. 刘文轩，孙文献，陈佩度，刘大钧. 1998, 将大赖草种质转移给普通小麦的研究 VII. 一个普通小麦-大赖草等臂染色体异附加系的选育与鉴定。遗传学报, 25（4）：351-355
专利申请：
1. 一种从种传和土传媒介中定量检测稻曲病菌的方法，排名第1，2016年1月，中国国家知识产权局；
2. 一种球囊霉属真菌与芽孢杆菌的组合菌剂及其应用，排名第3，2015年5月，中国国家知识产权局；
专利名称 |
专利号 |
专利单位 |
申请日--公告日 |
本人排名/总人数 |
一种从种传和土传媒介中定量检测稻曲病菌的方法 |
ZL 2014 1 0259131. 1 |
中国农业大学 |
2014.6.11 2016.1.20 |
1/6孙文献(#); 韩彦卿; 彭军; 张楠; 方安菲; 张亢 |
一种球囊霉属真菌与芽孢杆菌的组合菌剂及其应用 |
CN 201510045329. 4 |
青岛农业大学 |
2015.1.29 2015.5.27 |
3/4刘润进; 谭树朋; 孙文献; 黄金光 |
奖励：
1. 小麦异染色体系及近缘物种的细胞与分子遗传学研究。中国教育部科学与技术进步一等奖， 1999. 排名第八
2. 2015年度辽宁省科技进步三等奖“耐盐高抗水稻新品种盐粳456选育及应用”，排名第六
承担科研项目：
1. 国家自然科学基金区域创新发展联合基金（U19A2027），粳稻抗病新种质资源筛选与鉴定及其抗病分子机制研究，2020.1-2023.12，263万元，在研，主持
2. 吉林省技术攻关项目（20190303002SF），基于水稻病害生态防控的农药面源污染治理技术，2019.1-2021.12，50万元，在研，主持
3. 北京市自然科学基金重点项目（6181001），稻曲病菌中稻曲菌素的合成调控机制及其毒性研究，2018.1-2021.12 ，80万元，在研，主持
4. 国家自然科学基金面上项目（31770140）， 细菌性条斑病菌效应蛋白XopE35抑制水稻免疫的分子机理，2018.1-2021.12， 60万元，在研，主持
5. 国家自然科学基金重点项目 (31630064)，稻曲病菌致病关键效应蛋白的鉴定及其毒性功能的分子机理， 2017.1-2021.12， 284万元，在研，主持
6. 国家自然科学基金面上项目 (31471728)，稻曲病菌中稻曲菌素与黑粉菌素合成基因的鉴定及功能分析，2015.1-2018.12， 100万元，在研，主持
7. 农业部公益性行业专项（20130315）作物细菌性病害防控技术研究与示范 ， 2013.1-2017.12, 144万元，已结题，任务主持
8. 国家自然科学基金面上项目 (31272007)，水稻中 XA21 同源蛋白对条斑菌分子模式Ax21 的识别研究，2013.1-2016.12， 75万元，已结题，主持
9. 国家863计划项目（2012AA100703），农林有害生物分子生态调控技术研究，2012.1-2015.12，100万元，已结题，参与
10. 国家科技支撑计划（2012BAD19B03）课题名称：水稻重大病虫害防控技术研究与集成示范，子课题名称，水稻抗病性研究及北方稻区技术集成示范， 2012.1-2016.12，92万元，已结题，子课题主持
11. 国家973计划项目（2011CB100700）植物免疫机制与作物抗病分子设计的重大基础理论，2011.1-2015.10，111万元，已结题，参与
12. 国家自然科学基金 面上项目(30971893)，白叶枯菌与细菌性条斑菌鞭毛蛋白诱导水稻防卫反应的研究， 2010.1-2012.12，34万元，已结题，主持.
13. 教育部博士点基金（20090008110021），水稻OsFLS2对白叶枯菌与细菌性条斑菌鞭毛蛋白识别能力的研究，2010.1-2012.12，6万元，已结题，主持
14. 教育部留学回国人员启动基金，病原菌相关的分子模式（PAMP）诱导的基本防卫反应在水稻抗病育种中的应用，2010.1-2012.12，5万元，已结题，主持
15. 教育部新世纪优秀人才支持计划，NCET-09-0736，新世纪优秀人才，2010.1-2012.12，50万元，主持
16. 转基因重大专项2012ZX08009003, 小麦抗赤霉病基因的克隆与功能验证，2012.1- 2015.12，115万元，已结题，参加
17. 农业部公益性行业专项（200903039-6）子课题，稻曲病控制技术的研究，起止时间：2009.6-2013.12， 148万元，已结题，子课题主持
18. 转基因重大专项（2009ZX08010-004B），2009.6-2010.12，112万元，已结题，主持
